Inhibition of the Renin-Angiotensin System Prevents Re-Hospitalization of Heart Failure Patients With Preserved Ejection Fraction
نویسندگان
چکیده
منابع مشابه
Renin–Angiotensin System Inhibition, Worsening Renal Function, and Outcome in Heart Failure Patients With Reduced and Preserved Ejection Fraction
In the past 3 decades, the introduction of renin–angiotensin aldosterone system (RAAS) inhibitors has significantly improved morbidity and mortality in chronic heart failure (HF) patients with reduced ejection fraction (HFREF). Although RAAS inhibitors have beneficial effects on the heart and vasculature, they also induce a small decrease in renal function as estimated by glomerular filtration ...
متن کاملrenin-angiotensin system antagonists might reduce mortality in heart failure with preserved ejection fraction For heart failure with preserved ejection fraction (HF-
For heart failure with preserved ejection fraction (HFPEF), there is yetno evidence available of therapies reducing mortality. Three randomized clinical trials (RCTs), CHARM preserved, PEP-CHF and I-Preserve, investigated the role of renin-angiotensin system antagonists (RASA) -angiotensin II receptor blockers (ACEIs) and angiotensin II receptor blockers (ARBs) in this settingand failed to show...
متن کاملRelationship between intrarenal renin-angiotensin activity and re-hospitalization in patients with heart failure with reduced ejection fraction
OBJECTIVE Heart failure (HF) is a clinical syndrome resulting from structural or functional damages. Although clinical trials have shown that the plasma renin-angiotensin system (RAS) activation decreases HF functional status and increases hospitalization for HF patients, the effect of intrarenal RAS activity is still unknown. In this study, we investigated the relationship between the New York...
متن کاملAssociation between use of renin-angiotensin system antagonists and mortality in patients with heart failure and preserved ejection fraction.
CONTEXT Heart failure with preserved ejection fraction (HFPEF) may be as common and as lethal as heart failure with reduced ejection fraction (HFREF). Three randomized trials of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ie, renin-angiotensin system [RAS] antagonists) did not reach primary end points but may have had selection bias or been underpowered. OBJECTI...
متن کاملRenin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction
Animal models have suggested a role of renin-angiotensin system (RAS) activation and subsequent cardiac oxidation in heart failure with preserved ejection fraction (HFpEF). Nevertheless, RAS blockade has failed to show efficacy in treatment of HFpEF. We evaluated the role of RAS activation and subsequent systemic oxidation in HFpEF. Oxidative stress markers were compared in 50 subjects with and...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2008
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-08-0621